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Related Concept Videos

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids01:25

Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids

Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Drugs Used in Lower Respiratory Disorders: Overview01:17

Drugs Used in Lower Respiratory Disorders: Overview

Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
Acute Respiratory Failure-V01:29

Acute Respiratory Failure-V

The treatment for acute respiratory failure varies based on factors like the underlying cause, overall health, and severity. A collaborative healthcare team is essential for early detection, often through arterial blood gas analysis. Identifying the cause is the primary goal, with treatment strategies adjusted for ventilation/perfusion (V/Q) mismatch, shunting, or diffusion impairment.
Ensure that patients are monitored continuously for their response to therapy, including changes in...
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:

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Related Experiment Video

Updated: May 13, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Corticosteroids or NSAIDs in Managing Acute Respiratory Infections: Valuable Differences.

Francesco Scaglione1, Giorgio Ciprandi2

  • 1Department of Oncology and Hemato-Oncology, Postgraduate School of Clinical Pharmacology and Toxicology, University of Milan, Milan, Italy, unimi.it.

Journal of Immunology Research
|May 12, 2026
PubMed
Summary
This summary is machine-generated.

Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids (CSs) manage respiratory infection symptoms. NSAIDs are preferred for early viral infections to reduce fever and pain without impairing immunity, while CSs are reserved for severe cases and specific conditions like asthma.

Keywords:
acute respiratory infectionscorticosteroidsimmunityinflammationnonsteroidal anti-inflammatory drugsoxidative stress

Related Experiment Videos

Last Updated: May 13, 2026

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
09:36

Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device

Published on: September 24, 2020

Area of Science:

  • Pharmacology
  • Immunology
  • Infectious Diseases

Background:

  • Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids (CSs) are widely used for respiratory infections.
  • NSAIDs inhibit COX-1 and COX-2 enzymes, reducing prostaglandins involved in pain, fever, and inflammation.
  • CSs, while effective anti-inflammatories, carry risks like immunosuppression and metabolic changes, often overlooked at low doses.

Purpose of the Study:

  • To review the appropriate use of NSAIDs and CSs in managing respiratory infections.
  • To highlight the role of oxidative stress in infection-induced inflammation and the drugs' impact on it.
  • To differentiate the indications and potential risks of NSAIDs versus CSs in various respiratory conditions.

Main Methods:

  • Literature review and synthesis of current evidence on NSAID and CS use in respiratory infections.
  • Analysis of the mechanisms of action for both drug classes concerning inflammation and oxidative stress.
  • Comparison of clinical guidelines and research findings regarding efficacy and safety profiles.

Main Results:

  • NSAIDs are recommended for symptomatic relief (fever, pain) in early-stage infections, particularly viral ones, as they do not significantly hinder the immune response.
  • CSs are indicated for severe infections requiring ventilation and in patients with asthma or allergies, but not for general pain/fever relief due to immunosuppressive effects.
  • Both drug classes can mitigate oxidative stress associated with infections, but their use requires caution as they may mask serious underlying infections.

Conclusions:

  • NSAIDs are generally preferred for mild symptoms in early respiratory infections.
  • CSs have specific indications for severe disease or comorbid conditions but carry significant risks.
  • Careful consideration of drug class, infection severity, and patient factors is crucial for safe and effective treatment.