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Related Experiment Video

Updated: May 13, 2026

Preparation of Zinc Oxide Nanoparticles and the Evaluation of their Antibacterial Effects
06:42

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Published on: September 27, 2024

Prophylactic Protection Against Salmonella typhimurium Infection by Single-Atom Zinc Catalysts.

Ling Teng1,2,3, Hesheng Pan1, Zhongwei Chen2,3

  • 1Guangxi Key Laboratory of Animal Breeding, Disease Control and Prevention, College of Animal Science and Technology, Guangxi University, Nanning 530004, China.

Nanomaterials (Basel, Switzerland)
|May 12, 2026
PubMed
Summary

Single-atom zinc catalysts (SAC) prevent zinc agglomeration in poultry feed, improving bioavailability and reducing environmental zinc contamination. SAC also demonstrates potent antimicrobial effects and gut health benefits in chicks.

Keywords:
anti-S. typhimurium infectionantibacterial effectinternational healthintestinal florasingle-atom catalyst (SAC)

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Area of Science:

  • Materials Science
  • Animal Science
  • Environmental Science

Background:

  • Zinc oxide is crucial for poultry growth but agglomerates, leading to high doses, environmental contamination, and potential consumer safety risks.
  • Excreted, undigested zinc can enter the food chain, increasing residue probability in poultry tissues and eggs.

Purpose of the Study:

  • To develop and evaluate Metal-Organic Framework (MOF)-supported single-atom zinc catalysts (SAC) as an alternative to zinc oxide for poultry.
  • To assess SAC's bioavailability, antimicrobial properties, stability, and efficacy in controlling *Salmonella typhimurium* infection in poultry.

Main Methods:

  • SAC formation was verified using X-ray Diffraction (XRD) and Field Emission Scanning Electron Microscopy (FESEM).
  • Antimicrobial efficacy was tested against *Salmonella typhimurium*, *Escherichia coli*, and *Staphylococcus aureus*.
  • In vivo studies involved 7-day-old chicks challenged with *S. typhimurium* to evaluate SAC's effects on inflammation, gut integrity, and microbiota.

Main Results:

  • SAC formation was confirmed, resolving zinc agglomeration and enhancing bioavailability.
  • SAC demonstrated potent antimicrobial activity (MIC 3.125 mg/mL, MBC 25 mg/mL) and stability across a wide temperature (20-80 °C) and pH (2-8) range.
  • In chicks, SAC reduced inflammation, bacterial adherence, and tissue lesions, while promoting gut homeostasis and increasing *Lactobacillus* abundance.

Conclusions:

  • MOF-supported single-atom zinc catalysts offer a promising solution to zinc agglomeration and environmental issues in poultry.
  • SAC exhibits significant potential for controlling poultry infections and improving gut health due to its antimicrobial properties and stability.