Related Experiment Video

Updated: May 13, 2026

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis
07:15

In vivo Macrophage Imaging Using MR Targeted Contrast Agent for Longitudinal Evaluation of Septic Arthritis

Published on: October 20, 2013

Comparison of Conventional versus Abbreviated MR Enterography: Assessing Disease Activity and Complications in Crohn

Jordi Rimola1, Sudha Anupindi2, Nunzia Capozzi3

  • 1IBD Unit, Department of Radiology, Hospital Clínic of Barcelona, CIBER-EHD, IDIBAPS, Carrer Villarroel 170, 08036 Barcelona, Spain.

Radiology
|May 12, 2026
PubMed

Insights

An abbreviated MR enterography (A-MRE) protocol shows high agreement for detecting Crohn disease activity and complications, comparable to standard contrast-enhanced MRE (CE-MRE). This simplified approach offers similar diagnostic performance, potentially improving efficiency in Crohn disease management.

Area of Science:

  • Radiology and Medical Imaging
  • Gastroenterology
  • Inflammatory Bowel Disease Research

Background:

  • Magnetic Resonance Enterography (MRE) is vital for managing Crohn disease (CD).
  • An abbreviated MRE (A-MRE) protocol, omitting contrast and antiperistaltic agents, may enhance efficiency and patient compliance.

Purpose of the Study:

  • To compare the diagnostic performance of A-MRE versus conventional contrast-enhanced MRE (CE-MRE).
  • To assess intrareader concordance and interreader agreement for detecting CD activity and complications using both MRE protocols.

Main Methods:

  • Secondary analysis of a prospective study involving 10 abdominal radiologists.
  • Radiologists reviewed MRE examinations from 60 CD participants using both A-MRE and CE-MRE protocols.
  • Gwet's first agreement coefficient (AC1) was used to assess interreader agreement and intrareader concordance for active inflammation, indicative features, and complications.

Main Results:

  • High and comparable interreader agreement for active intestinal disease was found between A-MRE (AC1, 0.87) and CE-MRE (AC1, 0.91).
  • Similar agreement levels were observed for strictures and penetrating complications between the two protocols.
  • Intrareader concordance between A-MRE and CE-MRE was nearly perfect (AC1 range, 0.86-1.00), and the simplified MR index of activity (sMaRIA) demonstrated high sensitivity for inflammation.

Conclusions:

  • The abbreviated MRE (A-MRE) protocol exhibits comparable interreader agreement to CE-MRE for evaluating Crohn disease activity and complications.
  • High intrareader concordance suggests A-MRE is a reliable alternative to CE-MRE.
  • A-MRE holds promise for efficient and effective Crohn disease assessment.

More Related Videos

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice09:50

Induction of Intestinal Graft-versus-host Disease and Its Mini-endoscopic Assessment in Live Mice

Published on: February 11, 2019

Related Concept Videos

Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by transmural...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Inflammatory Bowel Disease IV: Clinical Manifestations01:20

Inflammatory Bowel Disease IV: Clinical Manifestations

Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The disease course is marked...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Inflammatory Bowel Disease I: Introduction01:26

Inflammatory Bowel Disease I: Introduction

Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows “skip lesions” in which...