Related Experiment Video
Updated: May 13, 2026

Quantifiable and Inexpensive Cell-Free Fluorescent Method to Confirm the Ability of Novel Compounds to Chelate Iron
Published on: February 23, 2024
The role of iron in driving sex-biased differences in cancer
Aurosman Pappus Sahu1, James R Connor2
1Department of Neurosurgery, The Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA.
Abstract:
Sex is a critical determining factor in cancer incidence, pathogenesis, and outcome. These effects result from sexual differentiation influencing mechanisms that regulate both normal and cancer biology. Iron biology is sexually dimorphic in nature and plays a key role in tumorigenesis. Therefore, iron metabolism may be a key driver of sex-biased differences in cancer. In this article, we review and synthesize the existing literature examining iron's role in driving sex differences in tumor incidence, progression, response to therapy, and overall survival in different cancer types. We also explore models that could be useful in studying iron metabolism-driven sex differences in tumorigenesis.
Related Concept Videos
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
Cancer Prevention
Some...
Cancer Prevention
Some...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
The Periodic Table and Organismal Elements

