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A Microfluidic Chip for the Versatile Chemical Analysis of Single Cells

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Published on: October 15, 2013

Portable microfluidic titration using a cross-shaped microfluidic device and smartphone camera for on-site

Daina Numao¹, Nobuo Uehara¹, Arinori Inagawa²

¹School of Engineering, Utsunomiya University, 7-1-2, Yoto, , Utsunomiya, Tochigi, 321-8585, Japan.

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry

|May 12, 2026

Summary

This summary is machine-generated.

A portable microfluidic titration system uses a smartphone camera for onsite analysis. This innovative device accurately quantifies acid concentration in samples like hot-spring water.

Keywords:

Aqueous biphasic interface Image analysis Microfluidics Smartphone Titration

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Area of Science:

Analytical Chemistry
Microfluidics
Portable Analytical Devices

Background:

Conventional titration methods often require specialized laboratory equipment.
Onsite quantitative analysis is crucial for field applications.
Microfluidic devices offer miniaturization and potential for portable analytical systems.

Purpose of the Study:

To develop a portable microfluidic titration system utilizing a smartphone camera as a detector.
To optimize microfluidic device design for enhanced visual detection of the equivalence point.
To validate the system's accuracy for quantitative analysis of acid concentration.

Main Methods:

Design and evaluation of two cross-shaped microfluidic devices with different channel geometries.
Optimization of an expanding-channel device for improved visual equivalence point detection.
Smartphone-based image analysis of color changes using red channel intensity profiles.
Acid-base titration of hydrochloric acid using bromothymol blue indicator.

Main Results:

An expanding-channel microfluidic device demonstrated enhanced visibility of the equivalence point.
A linear correlation was established between measured distance and hydrochloric acid concentration (25-150 mM).
The system accurately analyzed acid concentration in a real hot-spring water sample, comparable to conventional methods.

Conclusions:

The developed portable microfluidic titration system provides reliable quantitative analysis.
The system eliminates the need for microscopes or specialized optical instruments.
This technology holds significant potential for accessible onsite analytical applications.