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Updated: May 14, 2026
07:16
Methods for the Discovery of Novel Compounds Modulating a Gamma-Aminobutyric Acid Receptor Type A Neurotransmission
Published on: August 16, 2018
Unlocking SLC6A15 (B0AT2): A Dual-Platform Approach To Accelerate Drug Discovery for Neuropsychiatric Disorders.
Kathrin Lotz1, Antje Pommereau1, Kim Leoni Lang1
1Sanofi, R&D, Integrated Drug Discovery, Industriepark Höchst, 65926 Frankfurt am Main, Germany.
Analytical Chemistry
|May 12, 2026
Summary
Researchers developed a new screening method to find drugs targeting SLC6A15, a transporter linked to brain function and neuropsychiatric disorders. This approach aims to accelerate the discovery of novel therapeutics for neurological conditions.
Area of Science:
- Neuroscience
- Molecular Biology
- Pharmacology
Background:
- The solute carrier family 6 member 15 (SLC6A15), also known as B0AT2, is a sodium-dependent neutral amino acid transporter.
- Predominantly expressed in the central nervous system, SLC6A15 plays a role in amino acid transport, influencing neurotransmission and behavior.
- Dysregulation of SLC6A15 is implicated in neuropsychiatric disorders, making it a potential therapeutic target.
Purpose of the Study:
- To develop and validate a novel, high-throughput screening strategy for identifying modulators of SLC6A15.
- To advance drug discovery efforts for neuropsychiatric disorders by targeting SLC6A15.
Main Methods:
- A dual-platform screening approach was developed, integrating Acoustic Droplet Ejection-Mass Spectrometry (ADE-MS) with Solid Supported Membrane (SSM) electrophysiology.
- This method allows for sensitive and physiologically relevant assessment of SLC6A15 activity.
Main Results:
- The integrated ADE-MS and SSM electrophysiology platform offers enhanced throughput and sensitivity compared to conventional screening methods.
- This novel approach is poised to accelerate the identification of novel SLC6A15 inhibitors and activators.
Conclusions:
- The developed dual-platform screening strategy provides a powerful tool for SLC6A15 drug discovery.
- This approach has the potential to significantly impact the development of therapeutics for neuropsychiatric conditions by enabling efficient identification of SLC6A15 modulators.
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