Reproducibility of Two Novel Bone Defect Classification Systems
Related Experiment Video
Updated: May 14, 2026

Establishment of a Segmental Femoral Critical-size Defect Model in Mice Stabilized by Plate Osteosynthesis
Published on: October 12, 2016
Sean T Campbell1, Julie Agel2, Ashley E Levack3
1Department of Orthopaedic Surgery, University of California Davis, Davis, CA.
Objectives:
To determine the reproducibility of 2 novel bone defect classification systems, the Tetsworth classification system and the universal long bone defect (ULBD) classification system.
Methods:
Two independent reproducibility studies were undertaken. A series of cases with bone defects was collected and sent to a panel of orthopaedic surgeons who were members of the OTA or Limb Lengthening and Reconstruction Society who routinely manage bone defects. The surgeons were provided with a measurement calibration scale for defect length assessment. Analysis of reproducibility was performed using a Fleiss multirater kappa model, where a Fleiss kappa of 0 indicated agreement no better than random chance, and 1 indicated perfect agreement. Surgeons also rated their confidence in their rating from 1 to 3, with 3 as "very confident."
Results:
For the Tetsworth classification, the Fleiss kappa was 0.264 for the overall classification system (fair agreement) (95% CI, 0.224-0.305). The kappa for the D1, D2, D3 part of the code related to defect completeness (incomplete, subcritical, or critical) was 0.557 (moderate agreement) (95% CI, 0.446-0.648). The kappa for the A, B, C part of the code related to defect shape was 0.402 (moderate agreement) (95% CI, 0.323-0.480). The mean confidence for all cases was 2.46 (range, 1.86-3). For the ULBD classification, the Fleiss kappa for the entire classification was 0.133 (slight agreement) (95% CI, 0.123-0.144). The kappa for the location and segment was 0.568 (moderate agreement) (95% CI, 0.526-0.610). The kappa for the morphology component was 0.124 (slight agreement) (95% CI, 0.114-0.135). The mean confidence for all cases was 2.0 (range, 1.0-3.0).
Conclusions:
The bone defect classification system proposed by Tetsworth et al was reproducible by surgeons familiar with bone defects. The system can be considered for future research use. The ULBD classification system had low overall reproducibility.
Level Of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Related Concept Videos
Classification of Bones
Long and Short Bones
The appendicular skeleton, particularly the upper and lower limbs, is primarily made of long and short bones. The long...
Bone Remodeling
