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Morten Yung Isaksen1, Siw Leiknes Ernstsen2, Håkon Reikvam1

  • 1Medisinsk klinikk, Haukeland universitetssjukehus, og, K.G. Jebsen-senter for myeloid blodkreft, Klinisk Institutt 2, Universitetet i Bergen.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|May 12, 2026
PubMed
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This summary is machine-generated.

Post-transfusion purpura, a rare condition causing platelet destruction after blood transfusions, was successfully treated. Plasma exchange and IVIG resolved severe thrombocytopenia and bleeding in a patient with high anti-HPA-1a antibodies.

Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Post-transfusion purpura (PTP) is a rare complication.
  • Characterized by paradoxical destruction of autologous platelets 5-10 days post-transfusion of cellular blood products.

Purpose of the Study:

  • To report a case of PTP in a multiparous woman.
  • To highlight the diagnostic and therapeutic approach for PTP.

Main Methods:

  • A middle-aged multiparous woman presented with bleeding and severe thrombocytopenia post-platelet transfusion.
  • Diagnosed with PTP based on high anti-HPA-1a antibody levels and platelet auto-reactivity.
  • Treated with plasma exchange and intravenous immunoglobulin (IVIG).

Main Results:

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  • Initial treatment with steroids and IVIG was ineffective.
  • Plasma exchange led to rapidly rising platelet counts and resolution of bleeding.
  • Antibody levels decreased, and sustained normal platelet counts were achieved.

Conclusions:

  • PTP can present with severe thrombocytopenia and bleeding.
  • Plasma exchange combined with IVIG is an effective treatment for PTP.
  • The findings support the hypothesis of an HPA-incompatible transfusion triggering a secondary autoreactive process.