Related Experiment Video
Updated: May 14, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
Published on: April 28, 2016
Rational Sequence Modification Upgrades a Food-Derived Peptide into a Stronger Dual-Functional Regulator of
Xiang Wang1,2,3, Yejun Deng1,2,3, Junhao Wan4
1National Key Laboratory for Development and Utilization of Forest Food Resources, Institute of Chemical Industry of Forest Products, Chinese Academy of Forestry, Nanjing 210042, China.
None:
Inhibition of α-glucosidase and improvement of insulin resistance (IR) are key strategies for treating type 2 diabetes mellitus (T2DM). Our previous work obtained a novel α-glucosidase inhibitory peptide, FAPSW. However, its activity was weaker than acarbose. To further enhance its activities, 17 novel peptides were constructed by amino acid substitution using FAPSW as a template. Among them, YAPSW (IC50 = 0.126 ± 0.008 mM) exhibited stronger α-glucosidase inhibition than FAPSW and acarbose. Molecular docking suggested that hydrogen bonds were not the sole determinants of peptide-mediated α-glucosidase inhibition, while molecular dynamics simulations revealed that the enhanced inhibitory activity of YAPSW primarily resulted from its more stable binding to 3A4A. Moreover, FAPSW and YAPSW could improve IR and YAPSW exhibited stronger effects on IRS-1/PI3K/AKT signaling pathway than FAPSW. This study provides insights into optimizing α-glucosidase inhibitory peptides and supports the potential application of YAPSW as a multifunctional food ingredient for T2DM management.
Related Concept Videos
Glucagon-like Receptor Agonists
GLP-1, when administered in high doses intravenously, triggers insulin secretion, inhibits glucagon release, slows gastric emptying, reduces food intake, and restores normal insulin secretion. However, its rapid inactivation by the...
Dipeptidyl Peptidase 4 Inhibitors
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are typically...
Insulin: Biosynthesis, Chemistry, and Preparation
Damage or functional impairment of β-cells inhibits insulin production, leading to diabetes. Diabetes treatment primarily uses...
Oral Hypoglycemic Agents: Glinides
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
