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Published on: July 20, 2022
Preoperative Diastolic Dysfunction and Perioperative Risk Factors as Predictors of New Onset Atrial Fibrillation in
Yan Efrata Sembiring1,2, Lyndon Darwin1,2, Achmad Lefi3,4
1Universitas Airlangga Faculty of Medicine Department of Thoracic Cardiac and Vascular Surgery Surabaya Indonesia Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia.
Insights
New-onset postoperative atrial fibrillation (POAF) after coronary artery bypass grafting (CABG) is common. This study found preoperative diastolic dysfunction does not predict POAF, but identified other key risk factors.
Area of Science:
- Cardiology
- Cardiac Surgery
- Electrophysiology
Background:
- Postoperative atrial fibrillation (POAF) is a frequent complication after coronary artery bypass grafting (CABG).
- The underlying mechanisms of POAF are not fully understood, but impaired diastolic function is suspected.
- Identifying predictors of POAF is crucial for patient management and risk stratification.
Purpose of the Study:
- To investigate preoperative diastolic dysfunction (DD) as a predictor of new-onset POAF in patients undergoing CABG.
- To identify other associated factors that may predict new-onset POAF following CABG.
Main Methods:
- Retrospective cohort study of 191 patients undergoing CABG between January 2018 and August 2022.
- Preoperative diastolic dysfunction assessed via transthoracic echocardiogram.
- New-onset POAF monitored using continuous electrocardiogram.
Main Results:
- No significant difference in preoperative diastolic dysfunction was observed between patients with and without POAF (P = 0.72).
- Independent predictors of new-onset POAF included left main coronary artery disease (LMCAD), in-stent restenosis (ISR) ≥ 70%, reduced ejection fraction (≤ 50%), and electrolyte imbalance.
- Specific odds ratios and confidence intervals were reported for each identified predictor.
Conclusions:
- Preoperative diastolic dysfunction is not a predictor of new-onset POAF in CABG patients.
- Male sex, LMCAD, ISR ≥ 70%, reduced left ventricular ejection fraction, and postoperative electrolyte imbalance are significant predictors of POAF.
- These findings can aid in identifying high-risk patients for POAF after CABG.
Introduction:
Despite advancements in technique and the increasing number of coronary artery bypass grafting (CABG) procedures, new-onset postoperative atrial fibrillation (POAF) is one of the most common complications following CABG and remains a major concern. The exact mechanism is unclear, but impaired diastolic function may predispose patients to POAF. Thus, this study aims to evaluate preoperative diastolic dysfunction (DD) and associated factors as predictors of new-onset POAF.
Methods:
This retrospective cohort study involved patients undergoing CABG surgery who met the inclusion criteria between January 2018 to August 2022. DD was measured through preoperative transthoracic echocardiogram, while new-onset POAF was assessed through continuous electrocardiogram.
Results:
A total of 191 patients who met the inclusion criteria were enrolled in this study. Data-analysis revealed no significant difference in DD between patients with and without POAF (P = 0.72). Multivariate analysis demonstrated left main coronary artery disease (LMCAD) (odds ratio [OR] = 2.51; 95% confidence interval [CI] [1.12 - 5.59]; P = 0.02), in-stent restenosis (ISR) ≥ 70% (OR = 6.34; 95% CI [1.68 - 23.92]; P < 0.01), reduced ejection fraction ≤ 50% (OR = 2.18; 95% CI [0.94 - 5.06]; P = 0.07), and electrolyte imbalance (OR = 2.14; 95% CI [2.91 - 24.75]; P < 0.01) as the independent predictors of new-onset POAF.
Conclusion:
DD was not identified as a predictor of new-onset POAF in patients undergoing CABG. The independent predictors identified in this study included male sex, comorbid LMCAD and ISR ≥ 70%, reduced left ventricular ejection fraction ≤ 50%, and postoperative electrolyte imbalance.
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