Related Experiment Video
Updated: May 14, 2026

A Simple and Efficient Method for Testing Immunomodulatory Agents for Generation of Tolerogenic Dendritic Cells from Human CD14+ Monocytes
Published on: April 11, 2025
Daredevil human cDC2s tame wild TSLP to promote tolerance
Abel Lopez Hernandez1, Marc Dalod1
1Aix Marseille University, CNRS, INSERM, CIML, Centre d'Immunologie de Marseille-Luminy, Turing Center for Living Systems, Marseille, France.
None:
Under homeostatic conditions, murine dendritic cells (DCs) undergo a tolerogenic activation termed homeostatic maturation, preventing autoimmunity by inducing tolerance to innocuous antigens; whether this process occurs in humans is unknown. In this issue of Immunity, Lu et al. report that splenic human type 2 DCs undergo homeostatic maturation under thymic stromal lymphopoietin (TSLP) instruction.
Related Concept Videos
Desensitization and Tachyphylaxis
Several...
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
Transduction
GPCR Desensitization

