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Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Layers of the Epidermis01:21

Layers of the Epidermis

The epidermis, the outermost layer of the skin, is composed of several distinct layers. From deep to superficial, the layers of the epidermis are as follows:
Stratum Basale
Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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Papillary Dermis01:11

Papillary Dermis

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Related Experiment Video

Updated: May 14, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Relating plaque psoriasis barrier function changes with the underlying skin morphology and physiology.

Sean E Mangion1, Joshua K Dalton2, James F Clarke3

  • 1School of Pharmacy and Biomedical Science, College of Health, Adelaide University, Adelaide, Australia; Therapeutics Research Centre, Basil Hetzel Institute for Translational Health Research, The Queen Elizabeth Hospital, Woodville, Australia; Sanofi-Aventis, Sydney, New South Wales, Australia.

Journal of Pharmaceutical Sciences
|May 12, 2026
PubMed
Summary

This study reveals that psoriasis significantly alters skin barrier function, increasing transepidermal water loss (TEWL) and affecting skin structure. These changes impact topical drug delivery in psoriatic skin.

Keywords:
Confocal microscopyPsoriasis vulgarisTopical drug deliveryTrans-epidermal water loss (TEWL)

Related Experiment Videos

Last Updated: May 14, 2026

Measuring Psoriasis Severity at Home
02:28

Measuring Psoriasis Severity at Home

Published on: March 1, 2024

Area of Science:

  • Dermatology and Pharmaceutical Sciences

Background:

  • The relationship between skin barrier function, morphology, and physiology in disease states like psoriasis is not well-documented.
  • Understanding these relationships is crucial for optimizing topical drug development and delivery.

Purpose of the Study:

  • To review existing literature on psoriasis skin structure and physiology.
  • To compare these findings with direct measurements from psoriatic lesions and healthy skin.
  • To investigate how skin barrier function and morphology in psoriasis may influence drug delivery.

Main Methods:

  • Literature review of psoriasis skin structure and physiology.
  • Measurement of transepidermal water loss (TEWL), dermal blood flow, stratum corneum (SC) thickness, viable epidermis thickness, SC cell width, hydration, temperature, pH, and hair follicle density.
  • Comparison of measurements between psoriatic lesions, non-lesional psoriatic skin, and healthy control skin from 28 participants each.

Main Results:

  • Psoriatic lesions showed significantly increased TEWL, dermal blood flow, SC thickness, viable epidermis thickness, and lower SC cell width compared to healthy skin.
  • Skin hydration was significantly reduced in psoriatic lesions.
  • Non-lesional psoriatic skin exhibited physiological characteristics similar to healthy skin.
  • No significant differences were found in skin elasticity, temperature, pH, or hair follicle density.

Conclusions:

  • Dermal blood flow, viable epidermal thickness, and SC dimensions are key determinants of TEWL in both healthy and psoriatic skin.
  • These structural and physiological differences likely influence drug transport, highlighting potential variations in topical medication efficacy between psoriatic and healthy skin.
  • While findings align with literature, data variability necessitates caution in generalizing results.