Related Experiment Video
Updated: May 14, 2026

Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
Spirocyclic polycyclic polyprenylated acylphloroglucinols from Hypericum henryi and their anti-inflammatory activity
Ting Yue1, Jiayue Zhang1, Xiuping Wang1
1School of Pharmacy, Anhui Medical University, Hefei 230032, People's Republic of China.
None:
Five undescribed spirocyclic polycyclic polyprenylated acylphloroglucinols, hypehenols A-E (1-5), together with eight known analogues were isolated from the aerial portions of Hypericum henryi. Among them, compounds 2 and 3 feature a novel 5/6/5/7 tetracyclic system. Their structures were identified by comprehensive analysis of spectroscopic data. The absolute configurations of compounds 1-5 were determined by experimental and calculated electronic circular dichroism (ECD) spectra, along with the Rh2(OCOCF3)4-induced CD method. The anti-inflammatory activity of all compounds was assessed in lipopolysaccharide (LPS)-induced RAW264.7 cells. Compounds 1-6 exhibited inhibitory activity on nitric oxide production, with IC50 values ranging from 10.29 ± 0.59 to 20.08 ± 2.73 μM. Further research indicated that compound 5 could downregulate the expression of TNF-α and IL-6.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Prostacyclin Receptor Agonists
These agonists bind to the IPR receptor situated on the plasma membrane of the pulmonary artery smooth muscle cells. This binding triggers a cascade of reactions known as the GS-AC-cAMP-PKA pathway. This pathway results in the relaxation of smooth muscle...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Acute Inflammation II: Local and Systemic Effects
Acute Inflammation I: Inflammatory Response