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Related Experiment Video

Updated: May 14, 2026

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats
09:54

A Recovery Cardiopulmonary Bypass Model Without Transfusion or Inotropic Agents in Rats

Published on: March 23, 2018

Randomized Clinical Trial Comparing Effects of Pulsatile vs Nonpulsatile Cardiopulmonary Bypass on Neurologic

Srihari Rajesh1, Kevsergül Dayi1, Marc J Lussier1

  • 1Penn State Hershey Pediatric Cardiovascular Research Center, Penn State College of Medicine, Penn State Health Children's Hospital, Hershey, Pennsylvania.

The Annals of Thoracic Surgery
|May 12, 2026
PubMed

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Summary

Perfusion modality did not impact S100B levels or neural injury in pediatric heart surgery patients. S100B measurements may not reliably predict neural injury after cardiopulmonary bypass.

Area of Science:

  • Cardiovascular Surgery
  • Pediatric Cardiology
  • Neuroscience

Background:

  • Congenital heart defects necessitate cardiopulmonary bypass (CPB).
  • Neural injury is a significant concern in pediatric patients undergoing CPB.
  • S100B protein is a biomarker for brain injury.

Purpose of the Study:

  • To investigate the effect of non-pulsatile versus pulsatile perfusion on S100B levels.
  • To assess the relationship between S100B levels and neural injury outcomes.
  • To evaluate S100B as a predictor of neural injury in pediatric congenital heart surgery.

Main Methods:

  • Secondary analysis of pediatric patients (<18 years) randomized to non-pulsatile or pulsatile perfusion.
  • S100B levels measured at five timepoints during and after CPB.

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  • Neural injury outcomes assessed through clinical evaluation and chart review.

    • Main Results:

    • No significant difference in S100B levels between non-pulsatile and pulsatile perfusion groups.
    • S100B levels were similar in patients with and without neural injury.
    • S100B levels increased during CPB, peaking one hour post-CPB.

    Conclusions:

    • Perfusion modality does not influence S100B levels in this patient cohort.
    • S100B measurements may lack sensitivity for predicting neural injury post-CPB.
    • Further research is needed to identify reliable biomarkers for neural injury in pediatric cardiac surgery.