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Related Concept Videos

Autism Spectrum Disorder01:19

Autism Spectrum Disorder

Autism spectrum disorder (ASD) is a neurodevelopmental condition marked by persistent deficits in social communication and interaction alongside restrictive and repetitive behaviors or interests. ASD is sometimes accompanied by intellectual impairment.
These core symptoms manifest differently among individuals, ranging from mild to severe. The disorder's complexity extends beyond its clinical presentation, encompassing a diverse range of biological, cognitive, and sociocultural influences.

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Related Experiment Video

Updated: May 14, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Habenula Alterations in Resting-State Functional Connectivity Among Autistic Individuals.

Chloe L Hampson1, Julio A Peraza2, Lauren M Guerrero2

  • 1Department of Physics, Florida International University, Miami, Florida; FIU Embrace Center for Advancing Inclusive Communities, Florida International University, Miami, Florida.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|May 12, 2026
PubMed
Summary
This summary is machine-generated.

Autism is linked to altered brain connectivity in the habenula, a key reward region. This study found atypical functional connectivity in autistic individuals, impacting social behaviors and development.

Keywords:
AutismHabenulaResting stateSeed-based functional connectivityfMRI

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Related Experiment Videos

Last Updated: May 14, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism
08:44

Dynamic Clamp Methods to Investigate Impaired Neuronal Excitability Associated with Autism

Published on: October 17, 2025

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms
08:36

Dynamic Inter-subject Functional Connectivity Reveals Moment-to-Moment Brain Network Configurations Driven by Continuous or Communication Paradigms

Published on: March 21, 2019

Area of Science:

  • Neuroscience
  • Autism Spectrum Disorder Research
  • Brain Imaging and Connectomics

Background:

  • The reward-based framework of autism implicates altered reward circuitry in core symptoms.
  • Previous research identified structural changes in the habenula in autism, but functional connectivity (FC) remains understudied.

Purpose of the Study:

  • To investigate alterations in habenula functional connectivity (FC) in autism spectrum disorder (ASD).
  • To explore age-related developmental trajectories and brain-behavior relationships of habenula FC in autism.

Main Methods:

  • Utilized resting-state functional magnetic resonance imaging (rs-fMRI) data from 1,479 participants in the Autism Brain Imaging Data Exchange (ABIDE).
  • Performed whole-brain FC analysis with subject-specific habenula seeds.
  • Conducted regression analyses to examine age and behavioral correlations.

Main Results:

  • Autistic participants showed significantly increased habenula connectivity with the temporal gyri compared to neurotypical controls.
  • Autistic adolescents exhibited an accelerated developmental trajectory of habenula FC with the cingulate gyrus.
  • Habenula hyperconnectivity was inversely associated with social motivation and communication scores.

Conclusions:

  • This study provides novel evidence of altered habenula functional connectivity in autism, particularly with sensory processing regions.
  • Habenula circuitry development differs in autistic adolescents, with links to social behaviors.
  • Findings support the role of the dopaminergic reward system in the pathophysiology of autism.