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High-resolution In Vivo Manual Segmentation Protocol for Human Hippocampal Subfields Using 3T Magnetic Resonance Imaging
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Hippocampal Total, Subregion, and Subfield Volume Alterations in Late-Life Depression

Brianca Renfro1, Sarah M Szymkowicz1, Ke Xu2

  • 1Center for Cognitive Medicine, Department of Psychiatry and Behavioral Science, Vanderbilt University Medical Center, Nashville, Tennessee.

Biological Psychiatry. Cognitive Neuroscience and Neuroimaging
|May 12, 2026
PubMed
Summary

Late-life depression (LLD) is associated with smaller hippocampal volumes, particularly in currently depressed individuals. This study found no evidence of accelerated brain aging in LLD patients.

Keywords:
AgingDepressionDepressive disorderGeriatricHippocampus

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