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Mitral Stenosis III: Medical Management

Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
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Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
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Erratum to Author Corrections to: "Canadian Cardiovascular Society 2023 Guidelines on the Fitness to Drive [Canadian Journal of Cardiology, Volume 40, Issue 4 500-523, DOI: 10.1016/j.cjca.2023.09.033]".

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Related Experiment Video

Updated: May 14, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Long-Term Outcomes in Patients With New-Onset Left Bundle Branch Block Following TAVR.

Carla Benavent-García1, Marisa Avvedimento1, Pedro Cepas-Guillén2

  • 1Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada.

JACC. Cardiovascular Interventions
|May 12, 2026
PubMed
Summary

New-onset persistent left bundle branch block (NOP-LBBB) after TAVR increases long-term cardiovascular mortality and sudden death risk. Patients with NOP-LBBB also face a higher likelihood of progressive left ventricular dysfunction.

Keywords:
LBBBTAVRheart failureleft bundle branch blockpacemakertranscatheter aortic valve replacement

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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
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Last Updated: May 14, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Cardiac Electrophysiology

Background:

  • New-onset persistent left bundle branch block (NOP-LBBB) is a common complication after transcatheter aortic valve replacement (TAVR).
  • The long-term prognostic implications of NOP-LBBB following TAVR remain incompletely understood.
  • Understanding these risks is crucial for patient management and risk stratification post-TAVR.

Purpose of the Study:

  • To evaluate the long-term clinical and echocardiographic outcomes in patients who develop NOP-LBBB after TAVR.
  • To determine the association between NOP-LBBB and adverse events up to 10 years post-TAVR.
  • To identify specific risks, such as mortality and ventricular dysfunction, linked to NOP-LBBB.

Main Methods:

  • A cohort of 1,052 patients without prior LBBB or pacemaker implantation undergoing TAVR was analyzed.
  • NOP-LBBB was defined as new LBBB persisting at discharge after TAVR.
  • Clinical and echocardiographic data were prospectively collected with a median follow-up of 5 years.

Main Results:

  • NOP-LBBB was identified in 29.6% of patients (312/1052).
  • Patients with NOP-LBBB exhibited a significantly higher rate of the composite endpoint of cardiovascular mortality or heart failure hospitalization (37.5% vs. 31.5%; aHR: 1.37).
  • This was primarily driven by increased cardiovascular mortality (30.5% vs. 23.8%; aHR: 1.46), including a higher risk of sudden death (4.2% vs. 1.5%; aHR: 3.52), and a greater incidence of left ventricular ejection fraction decline.

Conclusions:

  • NOP-LBBB following TAVR is associated with adverse long-term outcomes.
  • These include elevated risks of cardiovascular mortality, sudden cardiac death, and progressive left ventricular dysfunction.
  • Tailored follow-up and risk stratification are essential for patients with NOP-LBBB post-TAVR.