Related Experiment Video
Updated: May 14, 2026
08:43
An Orthotopic Bladder Tumor Model and the Evaluation of Intravesical saRNA Treatment
Published on: July 28, 2012
Neoadjuvant Intravesical Therapy for Patients with Non-muscle-invasive Bladder Cancer: A Systematic Review and
Paolo Zaurito1, Pietro Scilipoti1, Alfonso Santangelo1
1Division of Experimental Oncology, Unit of Urology, Urological Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy; Vita-Salute San Raffaele University, Milan, Italy.
European Urology Oncology
|May 12, 2026
Summary
Neoadjuvant intravesical therapy before trans-urethral resection of bladder tumor (TURBT) significantly improves recurrence-free survival (RFS) in non-muscle-invasive bladder cancer (NMIBC) patients. This approach shows higher short-term RFS without severe adverse events, warranting further research.
Area of Science:
- Urology
- Oncology
- Clinical Trials
Background:
- Non-muscle-invasive bladder cancer (NMIBC) frequently recurs after trans-urethral resection of bladder tumor (TURBT).
- Neoadjuvant intravesical therapy before TURBT is a potential strategy to reduce recurrence, but evidence is limited.
Purpose of the Study:
- To systematically review and meta-analyze prospective studies.
- To assess recurrence-free survival (RFS) outcomes for neoadjuvant intravesical therapy followed by TURBT versus upfront TURBT.
Main Methods:
- Comprehensive search of PubMed, Scopus, Embase, and Web of Science for prospective studies.
- Inclusion of studies with neoadjuvant intravesical treatment followed by TURBT.
- Meta-analysis of recurrence-free survival (RFS) data.
Main Results:
- Neoadjuvant intravesical therapy followed by TURBT demonstrated significantly higher 1-, 2-, and 3-year RFS rates compared to upfront TURBT.
- Hazard Ratio for recurrence was 0.42 (95% CI: 0.29-0.61, p < 0.001) favoring neoadjuvant therapy.
- No grade 3-5 adverse events were reported with neoadjuvant intravesical therapy.
Conclusions:
- Neoadjuvant intravesical therapy before TURBT improves short-term RFS in NMIBC patients.
- The treatment is associated with a favorable safety profile regarding severe adverse events.
- Further adequately powered randomized trials are needed to confirm benefits and guide clinical adoption.
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