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Updated: May 14, 2026

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance
08:45

Whole Genome Sequencing of Candida glabrata for Detection of Markers of Antifungal Drug Resistance

Published on: December 28, 2017

Emerging antifungal resistance: an updated review on current scenario, pathogens involved and tackling strategies

Sanchita Mitra1,2

  • 1Jhaveri Microbiology Centre and Prof. Brien Holden Eye Research Centre, LV Prasad Eye Institute, Hyderabad, India.

Future Microbiology
|May 12, 2026
PubMed

Insights

Antifungal resistance (AFR) is a growing global threat, exacerbated by limited diagnostics and treatments. This review addresses key challenges and novel strategies for managing AFR in humans and animals.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Public Health

Background:

  • Antifungal resistance (AFR) is an escalating global health concern, yet it receives less attention than antibacterial resistance.
  • AFR incidence is rising in both immunocompromised and immunocompetent individuals, complicated by factors like zoonotic potential and limited diagnostics.

Purpose of the Study:

  • To compile current information, advances, and perspectives on the major challenges in the origin and management of antifungal resistance.
  • To systematically review existing literature on antifungal resistance, focusing on environmental drivers, the "One Health" perspective, and climate change impacts.

Main Methods:

  • Conducted a systematic review of publications on standard databases using search terms related to antifungal resistance up to January 2026.
  • Focused on key aspects including environmental drivers, "One Health," climate change, fungal zoonoses, diagnostics, resistant pathogens, stewardship, and novel strategies.

Main Results:

  • Identified significant challenges in AFR management, including limited diagnostics, a narrow antifungal pipeline, and cross-resistance issues.
  • Highlighted the need for robust antifungal stewardship programs and explored emerging fungal zoonoses and their links to environmental factors.

Conclusions:

  • AFR presents a complex, multifaceted threat requiring a "One Health" approach, integrating human, animal, and environmental health strategies.
  • Novel strategies, including mycoviruses and vaccines, show promise for combating AFR, alongside improved diagnostics and stewardship.
Keywords:
Antifungal resistanceantifungal stewardship programsantifungal susceptibility testingfungal diagnosticsfungal vaccinesfungal zoonosesmycovirusesone health and antifungal resistance

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