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Updated: May 14, 2026

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters
08:41

Differentiation of Human Pluripotent Stem Cells into Insulin-Producing Islet Clusters

Published on: June 23, 2023

Heterogeneous endocrine cell composition defines human islet functional phenotypes

Carmella Evans-Molina1,2,3,4,5,6,7, Yasminye D Pettway8, Diane C Saunders9

  • 1Departments of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA. cevansmo@iu.edu.

Nature Communications
|May 12, 2026
PubMed
Summary

Human islet cell composition varies significantly, impacting hormone secretion and type 2 diabetes risk. Understanding this heterogeneity is key for personalized diabetes medicine and cell therapy.

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