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RGD-modified alginate enhances viability, metabolic reprogramming, and cytokine secretion profiles in encapsulated

Kadriye Güven1, Anil Dhawan1,2, Celine Filippi3

  • 1DhawanLab, Roger Williams Institute of Liver Studies, King's College London, King's College Hospital, London, SE5 9RS, UK.

Scientific Reports
|May 12, 2026
PubMed
Abstract

No abstract available in PubMed .

Keywords:
Alginate microencapsulationCell therapyHIF1AMesenchymal stromal cellsMitochondrial biogenesisRGD-modified biomaterialsUmbilical cord-derived MSCs (UC-MSCs)

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Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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