Beyond BMI in interpreting sex-specific blood pressure trajectories: a comment on Kawasoe et al
1Department of Gastroenterology, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha), Changsha Hospital of Hunan Normal University, Changsha, China.
Insights
Body Mass Index (BMI) alone may hide distinct vascular aging patterns. Different health conditions, like osteoporosis or insulin resistance, correlate with specific blood pressure measures, suggesting a need for layered phenotyping.
Area of Science:
- Cardiovascular Health
- Aging Biology
- Metabolic Disorders
Background:
- Body Mass Index (BMI) is a common metric but may oversimplify complex health conditions.
- Vascular aging can manifest in diverse biological phenotypes not fully captured by BMI alone.
Abstract:
BMI alone may conceal biologically distinct vascular-aging phenotypes. In our external cohorts, osteoporosis tracked with wider pulse pressure and hypertension, while insulin resistance and triglycerides tracked with higher systolic blood pressure and pulse pressure, supporting layered phenotyping in future blood pressure-trajectory analyses.
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