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Identifying Optimal Drug Loading in Stable Amorphous Solid Dispersion Formulations: A Rheological Approach.

Sagar Narala1, Fengyuan Yang2, Kapish Karan1

  • 1Ashland Specialty Ingredients, Wilmington, DE, 19808, United States of America.

AAPS Pharmscitech
|May 12, 2026
PubMed
Summary

Formulation scientists can determine optimal polymer/API ratios for stable amorphous drug systems using rheological studies. This research highlights how drug solubility in copovidone impacts the physical stability of amorphous nifedipine formulations.

Keywords:
amorphous solid dispersioncopovidonehomogeneitymiscibilityrheologystability

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