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Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...

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Related Experiment Video

Updated: May 14, 2026

Microfluidic Chip for Axonal Injury Models Construction and Enabling Multi-Omics Analysis
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Published on: October 14, 2025

Nanozyme-Switched Efferocytosis Initiation Platform Orchestrates Pathological Network Reprogramming to Promote

Chang Li1, Zheng Cheng1, Yanwei He1

  • 1Department of Pharmaceutics, School of Pharmaceutical Sciences & Shanghai Pudong Hospital, Key Laboratory of Smart Drug Delivery, Ministry of Education, State Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Fudan University, Shanghai 201203, China.

ACS Nano
|May 12, 2026
PubMed
Summary

This study introduces CM-ApoV, a novel platform combining cell vesicles and nanozymes to combat spinal cord injury (SCI). CM-ApoV effectively reduces inflammation and oxidative stress, promoting nerve regeneration and improving motor function in SCI models.

Keywords:
ROS scavengingapoptotic vesiclesefferocytosismesenchymal stem cellsmetal-natural drug nanozymesspinal cord injury

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Published on: June 13, 2017

Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Neuroscience

Background:

  • Spinal cord injury (SCI) creates a hostile microenvironment characterized by oxidative stress and inflammation, hindering nerve regeneration.
  • Current single-target treatments offer limited benefits for the complex pathology of SCI.
  • Mesenchymal stem cell-derived apoptotic vesicles (ApoVs) possess immunomodulatory properties and expose 'eat me' signals (phosphatidylserine) for microglial interaction.

Purpose of the Study:

  • To develop a novel nanozyme-switched efferocytosis initiation platform (CM-ApoV) for multidimensional treatment of SCI.
  • To integrate cerium-melatonin nanozymes (Ce-MT) with ApoVs to enhance reactive oxygen species (ROS) scavenging and modulate microglial function.
  • To investigate the therapeutic efficacy of CM-ApoV in promoting neuronal survival and functional recovery after SCI.

Main Methods:

  • Development of CM-ApoV by integrating Ce-MT nanozymes onto ApoVs.
  • Utilizing the 'eat me' signal (phosphatidylserine) on ApoVs for targeted microglial efferocytosis.
  • Employing Ce-MT's ROS scavenging capacity and reversible PtdSer masking/unmasking mechanism.
  • Evaluating CM-ApoV's effects on neuronal survival, microglial function, glial scar formation, and motor function in a rodent SCI model.

Main Results:

  • CM-ApoV effectively scavenged ROS and modulated microglial function, reducing inflammation.
  • The platform promoted neuronal survival and decreased glial scar formation post-SCI.
  • Significant improvement in motor function was observed in the rodent SCI model treated with CM-ApoV.
  • The nanozyme-ApoV hybrid platform demonstrated synergistic therapeutic potential.

Conclusions:

  • CM-ApoV offers a feasible strategy for multidimensional treatment of SCI by remodeling the pathological microenvironment.
  • This nanozyme-switched efferocytosis platform holds promise for enhancing nerve regeneration and functional recovery after spinal cord injury.
  • The study highlights the synergistic therapeutic potential of combining nanozymes with extracellular vesicles for complex neurological disorders.