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Related Concept Videos

Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Inhibition of CDK Activity02:34

Inhibition of CDK Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
Cancer Prevention02:59

Cancer Prevention

Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...

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Related Experiment Video

Updated: May 14, 2026

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4-Hydroxychalcone Exert the Anti-cancer Potential in Colorectal Cancer Through Targeting CDK6.

Chenxin Yang1, Mingxuan Huangfu1, Xintong Dai2

  • 1School of Integrative Medicine, State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.

Biological Procedures Online
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

4-Hydroxychalcone (4HC) shows potent anticancer effects against colorectal cancer (CRC) by inhibiting CDK6. This natural compound induces cell cycle arrest, DNA damage, and senescence, offering a promising new therapeutic strategy for CRC.

Keywords:
4-HydroxychalconeCell senescenceColorectal cancerCyclin-dependent kinase 6DNA damage

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Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Colorectal cancer (CRC) is a leading cause of cancer mortality with high recurrence rates.
  • 4-Hydroxychalcone (4HC), a dietary chalcone, possesses known anticancer properties, but its specific role in CRC was undetermined.
  • Understanding novel therapeutic targets and agents for CRC is crucial.

Purpose of the Study:

  • To investigate the anticancer effects of 4-Hydroxychalcone (4HC) in colorectal cancer (CRC).
  • To elucidate the molecular mechanisms underlying 4HC's action in CRC.
  • To evaluate 4HC as a potential therapeutic strategy for CRC.

Main Methods:

  • In vitro and in vivo models of CRC, including patient-derived organoids and xenografts.
  • Assays for cell proliferation, cell cycle, reactive oxygen species (ROS), DNA damage, and senescence.
  • Molecular docking, CETSA, and SPR to identify 4HC's molecular target (CDK6).
  • Analysis of CDK6 expression in CRC tissues using TCGA and immunohistochemistry.

Main Results:

  • 4HC demonstrated significant anticancer effects in both in vitro and in vivo CRC models.
  • 4HC induced cell cycle arrest, increased ROS, DNA damage, and senescence in CRC cells.
  • 4HC directly binds to and inhibits CDK6, which is overexpressed in CRC tissues. Silencing CDK6 diminished 4HC's efficacy.

Conclusions:

  • 4-Hydroxychalcone (4HC) functions as a CDK6 inhibitor with potent anticancer activity against colorectal cancer.
  • 4HC represents a potential novel therapeutic agent for CRC treatment.
  • Targeting CDK6 with compounds like 4HC offers a promising strategy for managing CRC.