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Updated: May 14, 2026

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
Published on: December 2, 2014
Clinical measurements of aortic stiffness and peripheral resistance using a routine echocardiogram
Maggie Gudenkauf1, Senthil Kumar2, Noah D Manring2
1Mechanical and Aerospace Engineering, University of Missouri, Columbia, Missouri, USA.
Abstract:
Retrospective data for 259 patients is used to calculate aortic stiffness based on a new method which has been previously verified with in-vitro and in-hospital carotid-femoral Pulse Wave Velocity (cfPWV) studies. For this group of patients, it is shown that the greatest variability within the hemodynamic record is the aortic stiffness, followed by the peripheral resistance - both present risk factors for cardiovascular disease. Our research shows that elevated stiffness is observed in both hypotensive and hypertensive patients, while the peripheral resistance increases monotonically with hypertensive grade. Our research also shows that stiffness and resistance decrease with increasing BMI which may indicate secondary causes for the obesity paradox documented in previous studies.
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