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Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
Published on: May 9, 2022
Polymeric Nanoparticles for Modulating Reactive Oxygen Species in the Periodontitis Microenvironment
Suleiman Ibrahim Mohammad1,2, Asokan Vasudevan3,4, Ghaleb Oriquat5
1Electronic Marketing and Social Media, Economic and Administrative Sciences Zarqa University, Zarqa, Jordan.
Journal of Biochemical and Molecular Toxicology
|May 13, 2026
Summary
Reactive oxygen species (ROS) responsive nanoparticles offer a novel approach to treating periodontitis. These advanced nanocarriers target ROS accumulation, enhancing therapeutic delivery for improved periodontal disease management.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Periodontology
Background:
- Periodontitis is a chronic inflammatory gum disease driven by bacterial infection and host immune response.
- Localized reactive oxygen species (ROS) accumulation causes oxidative stress, damaging periodontal tissues.
- Current treatments aim to reduce bacteria, scavenge ROS, and mitigate inflammation and bone loss.
Purpose of the Study:
- To review the potential of ROS-responsive polymeric nanoparticles for periodontitis treatment.
- To explore the ROS-sensitive properties of these nanocarriers.
- To assess their role in improving periodontitis management and therapeutic outcomes.
Main Methods:
- Literature review of studies on ROS-responsive nanoparticles in periodontitis.
- Analysis of nanocarrier design and ROS-sensitive mechanisms.
- Evaluation of therapeutic agent delivery and pharmacokinetic improvements.
Main Results:
- ROS-responsive nanoparticles demonstrate potential for targeted drug delivery in periodontitis.
- These nanocarriers can enhance treatment efficacy and reduce side effects.
- Smart delivery systems offer improved control over therapeutic agent release.
Conclusions:
- ROS-responsive polymeric nanoparticles represent a promising strategy for advanced periodontitis therapy.
- Their ability to target ROS accumulation and deliver therapeutics effectively warrants further investigation.
- This approach may lead to improved clinical outcomes in managing periodontal disease.
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