Related Experiment Video
Updated: May 14, 2026
Behavioral Approaches to Studying Innate Stress in Zebrafish
Published on: May 1, 2019
Transcriptomic Response and Molecular Adaptation Mechanisms of Common Carp (Cyprinus carpio) Intestine Under Dual
Xiaoying Jiang1,2, Junli Zheng2, Zilong Jiang1
1College of Fisheries, Hunan Agricultural University, Changsha 410128, China.
Abstract:
This study employed a 2 × 2 factorial design to investigate the transcriptomic responses of common carp intestine under the single and combined stress of high temperature and zinc. Results from Illumina RNA-seq, WGCNA, and qPCR showed high-quality sequencing data with good reproducibility. High temperature was the core driver of global transcriptomic reprogramming, inducing numerous DEGs via activating metabolic and stress signaling pathways. Zinc alleviated heat stress by reducing DEGs by 43.2% and activating DNA repair and cell cycle pathways. WGCNA identified core modules for heat response and zinc mitigation, revealing "emergency defense" and "repair adaptation" strategies. This study enriches the teleost stress adaptation theory and provides a scientific basis for healthy carp aquaculture.
Related Concept Videos
02:45Responses to Heat and Cold Stress
01:23Stringent Response in E. coli
02:02Responses to Salt Stress
01:30Other Stress Responses in Bacteria
01:10Transcription
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...