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Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...

Hedgehog Signaling Pathway

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Non-Canonical Wnt Signaling Pathways

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Related Experiment Video

Updated: May 14, 2026

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Monitoring Hippo Signaling Pathway Activity Using a Luciferase-based Large Tumor Suppressor (LATS) Biosensor

Published on: September 13, 2018

Research on the Hippo Pathway in Cancer.

Fengqiu Dang^1,2, Shuhuan Dai², Tianqi Zhao²

¹Pharmaceutical College, Guangxi Medical University, Nanning 530021, China.

|May 13, 2026

Summary

This summary is machine-generated.

The Hippo pathway, when inactivated, drives tumor growth, resistance, and immune evasion by affecting cancer cells and the tumor microenvironment. Understanding its regulation offers new anti-tumor strategies.

Keywords:

Hippo YAP/TAZ cancer-associated fibroblasts tumor microenvironment

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Published on: October 9, 2018

Area of Science:

Oncology
Cell Biology
Molecular Biology

Background:

The Hippo pathway is crucial for regulating cell proliferation, apoptosis, and organ development.
Abnormal Hippo pathway inactivation is linked to cancer onset, progression, metabolic reprogramming, drug resistance, and immune evasion.

Purpose of the Study:

To systematically review the Hippo pathway's composition, regulation, and mechanisms in tumor biology.
To explore the Hippo pathway's interactions within the tumor microenvironment (TME) and its role in anti-tumor drug development.

Main Methods:

Literature review of Hippo pathway functions in cancer.
Analysis of Hippo pathway's role in tumor cell behavior and TME modulation.
Review of current and emerging therapeutic strategies targeting the Hippo pathway.

Main Results:

Inactivated Hippo pathway promotes tumor cell proliferation, stemness, metabolic reprogramming, and treatment resistance.
The Hippo pathway influences the TME by regulating cancer-associated fibroblasts (CAFs) and immune cells (macrophages, T-cells).
A feedback loop exists where TME components negatively regulate Hippo activity, promoting tumor growth.

Conclusions:

The Hippo pathway is a critical regulator of tumor progression and immune evasion.
Targeting the Hippo pathway holds promise for novel anti-cancer therapeutic strategies.
Further understanding of Hippo pathway dynamics in the TME is essential for effective drug development.