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Updated: May 14, 2026
A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy
Published on: April 30, 2015
Understanding Sickle Cell Disease Endothelial Pathology Through the Lens of Liver Sinusoidal Endothelial Cells
Tirthadipa Pradhan-Sundd1, Brian Branchford1, Joan Beckman2
1Thrombosis and Hemostasis Research Program, Versiti Blood Research Institute, Milwaukee, WI 53226, USA.
Endothelial cell activation is one of the major pathophysiological aspects of sickle cell disease (SCD). In this review, we discuss the interaction of endothelial cells of various tissue beds, highlighting the specific biomarkers linked to endothelial cell activation and damage, and elaborate on endothelial cells' role in the development of acute and chronic organ damage in SCD using existing clinical and preclinical data. Finally, we focus on liver sinusoidal endothelial cells (LSECs) and their role in hemoglobin scavenging, sterile inflammation, and organ damage in SCD, as well as potential therapeutic strategies to reverse organ damage induced by LSEC dysfunction in SCD.
Endothelial cell activation is one of the major pathophysiological aspects of sickle cell disease (SCD). In this review, we discuss the interaction of endothelial cells of various tissue beds, highlighting the specific biomarkers linked to endothelial cell activation and damage, and elaborate on endothelial cells' role in the development of acute and chronic organ damage in SCD using existing clinical and preclinical data. Finally, we focus on liver sinusoidal endothelial cells (LSECs) and their role in hemoglobin scavenging, sterile inflammation, and organ damage in SCD, as well as potential therapeutic strategies to reverse organ damage induced by LSEC dysfunction in SCD.
