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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...

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Related Experiment Video

Updated: May 14, 2026

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
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An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues

Published on: January 7, 2019

Driveline Infections in Durable LVAD Support: Risk Factors, Microbiology, and Resistance Patterns from a Large

Umit Kahraman1, Oguzhan Acet2, Barkin Dost Bulut1

  • 1Department of Cardiovascular Surgery, Faculty of Medicine, Ege University, 35100 Izmir, Turkey.

Diagnostics (Basel, Switzerland)
|May 13, 2026
PubMed
Summary

Driveline infections (DLIs) affect 20.5% of left ventricular assist device (LVAD) patients. Diabetes and longer support duration are key risk factors for DLIs, alongside Staphylococcus aureus and Pseudomonas aeruginosa infections.

Keywords:
antimicrobial resistancedriveline infectionleft ventricular assist device

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Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
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Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

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Last Updated: May 14, 2026

An In Vitro Model of a Parallel-Plate Perfusion System to Study Bacterial Adherence to Graft Tissues
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Published on: January 7, 2019

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure
05:18

Implantation of Left Ventricular Assist Device (LVAD) in Juvenile Landrace Swine: A LVAD Implantation Model of Pediatric Heart Failure

Published on: January 16, 2026

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Devices

Background:

  • Driveline infection (DLI) is the most frequent device-related infection in ventricular assist device (VAD) patients.
  • DLIs contribute significantly to morbidity in patients requiring long-term mechanical circulatory support.

Purpose of the Study:

  • To determine the incidence, risk factors, and microbiological characteristics of DLIs in patients with durable left ventricular assist devices (LVADs).
  • To analyze antimicrobial resistance patterns associated with DLIs in LVAD recipients.

Main Methods:

  • Retrospective cohort study of 772 consecutive patients undergoing durable LVAD implantation.
  • Analysis of demographic, clinical, laboratory, and perioperative data.
  • Multivariate logistic regression to identify independent predictors of DLI; evaluation of microbiological isolates and antimicrobial resistance.

Main Results:

  • Driveline infection occurred in 20.5% of patients.
  • Independent predictors of DLI included diabetes mellitus (OR 3.29) and longer LVAD support duration.
  • Predominant pathogens were Staphylococcus aureus (36%) and Pseudomonas aeruginosa (19%), with significant antimicrobial resistance (e.g., fluoroquinolones, MRSA).

Conclusions:

  • Diabetes mellitus and prolonged LVAD support are primary independent predictors of driveline infection.
  • Staphylococcus aureus and Pseudomonas aeruginosa are the main causative agents, exhibiting concerning resistance patterns.
  • Metabolic optimization, meticulous site care, and surveillance are crucial for mitigating DLI risk in LVAD patients.