Optimizing Risk Communication for Lynch Syndrome: Results of a Randomized Controlled Trial of Visual Arrays for
Jordan N Keels1, Viktoriya Babicheva2, Isabella R McDonald1
1William F. Connell School of Nursing, Boston College, Chestnut Hill, MA 02467, USA.
Cancers
|May 13, 2026
Summary
Visualizing colorectal cancer risk in Lynch syndrome did not differ between standard and sequential icon arrays. Intention to share genetic test results with family was also unaffected by communication framing strategies.
Area of Science:
- Genetics
- Cancer Research
- Health Communication
Background:
- Lynch syndrome increases colorectal cancer (CRC) risk.
- Effective communication of genetic risk is crucial for hereditary cancer syndromes.
- Decision support tools can aid individuals in understanding complex genetic information.
Purpose of the Study:
- To evaluate two visual arrays for CRC risk interpretation in Lynch syndrome.
- To examine factors influencing the intention to share genetic test results with relatives.
Main Methods:
- Online survey with 1041 participants recruited via Amazon Mechanical Turk.
- Randomization to either a standard or sequential icon array for risk visualization.
- Randomization to a nondirective or enhanced choice frame for communication.
Main Results:
- No significant difference in CRC risk estimation between standard and sequential icon arrays (p=0.58).
- Behavioral nudges did not influence the intention to share genetic testing outcomes (p=0.23).
- Risk estimation and communication intent were not affected by individual risk perception, literacy, or history.
Conclusions:
- Visual array type does not impact estimated cancer risk perception.
- Communication framing does not affect the intent to share genetic test results.
- Findings may inform online decision support for hereditary cancer syndromes.
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