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Related Experiment Video

Updated: May 14, 2026

Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis
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Draining Lymph Node Metastasis Model for Assessing the Dynamics of Antigen-Specific CD8+ T Cells During Tumorigenesis

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T-Cell Clonal Expansion in Peripheral Blood Following Interventional Radiology Procedures for Metastatic Liver

Chenyang Zhan1, Anita Karimi1, Leila Haghani1

  • 1Interventional Radiology Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA.

Cancers
|May 13, 2026
PubMed
Summary

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Interventional radiology procedures for liver cancer may expand specific T-cells, but overall T-cell repertoire clonality remains unchanged. This study tracked T-cell clonotypes post-procedure, showing feasibility for monitoring immune responses.

Area of Science:

  • Immunology
  • Oncology
  • Interventional Radiology

Background:

  • Interventional radiology (IR) procedures can stimulate anti-tumor immune responses.
  • T-cell clonal expansion recognizing tumor antigens is a potential outcome.
  • Investigating T-cell dynamics post-IR for metastatic liver cancer is crucial.

Purpose of the Study:

  • To explore T-cell clonal expansion in peripheral blood after IR procedures for metastatic liver cancer.
  • To assess the impact of IR on the T-cell repertoire.

Main Methods:

  • Prospective study of 16 metastatic liver cancer patients undergoing IR (embolization/ablation).
  • Collected pre- and post-procedure peripheral blood and pre-procedure biopsy samples.
  • Utilized bulk T-cell receptor (TCR) sequencing for clonality analysis.
Keywords:
T-cell clonalityTCR sequencingablationembolizationmetastatic liver cancer

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Last Updated: May 14, 2026

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Isolation of CD133+ Liver Stem Cells for Clonal Expansion
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Published on: October 10, 2011

Main Results:

  • No significant overall change in peripheral blood T-cell repertoire clonality post-IR (p = 0.27-0.77).
  • 43% of patients showed limited T-cell clonal expansion one month after IR.
  • Most expansions decreased by three months, but 3 patients had persistent clonal expansion.

Conclusions:

  • IR procedures do not alter overall T-cell repertoire clonality but can expand specific T-cell clonotypes.
  • Feasible to detect and track expanding T-cell clonotypes after IR liver-directed therapy.
  • Further research needed to confirm if these clonotypes mediate systemic anti-tumor immunity.