Green-Synthesized Zinc Oxide-Bacterial Cellulose Composites: Eco-Friendly Antibacterial Wound Dressings for Faster...

The present work aimed to obtain antibacterial wound dressings using bacterial cellulose (BC) as a support, to improve wound treatment and reduce the incidence of infections. To enhance the antibacterial activity of the synthesized dressings, the introduction of ZnO nanoparticles into the BC network by precipitation was pursued. The method chosen to develop ZnO NPs was green synthesis, an ecological and sustainable method for obtaining nanomaterials using plant extracts as reducing agents or stabilizers. Thus, the chosen plants were Ginger rhizomes, Bay leaves, and Rose hips, in both fresh and dry form, due to the natural benefits they possess, and the Soxhlet method was used to obtain the plant extracts desired to be used in the synthesis. The composite dressings were developed in two distinct sample series, differentiated by the immersion time of BC in the precursor Zn²⁺ solution. The samples in the first series were obtained by precipitation in a mixture of Zn²⁺ solution and natural extract, whereas the samples in the second series were obtained by successive immersion in Zn²⁺ solution and then in natural extract, which demonstrated a considerable difference. The best antimicrobial activity tested against Gram-negative bacterium Escherichia coli was recorded for the composite material obtained in the presence of fresh rose hip extract, an aspect most likely related to the morphological and crystalline features of the ZnO phase, but also to the phytochemical profile of the extract used. Such eco-friendly materials represent valuable candidates for wound dressing applications due to their ability to support wound healing, relief burns, and skin irritation, provide antimicrobial protection, promote skin regeneration and reduce scarring, protect sensitive skin, and act as a barrier against external contaminants.