Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell-Friendly 3D Bioprinting of Gelatin-Norbornene Bioink via Thiol-Ene Crosslinking Enabled by Interfacial DTT Delivery from Alternating Support Layers.

ACS biomaterials science & engineering·2026
Same author

Functional Group Chemistry Modulates Cellular Responses to Soluble Gelatin Derivatives Independent of Crosslinking.

Biomolecules·2026
Same author

Phenol-grafted Aphanothece sacrum polysaccharide hydrogels with intrinsic angiogenic activity and enhanced in vivo vascularization.

International journal of biological macromolecules·2026
Same author

3D Printing of Cincau Perdu (<i>Premna oblongifolia</i>) Hydrogel for Dysphagia Patient's Food Application.

Foods (Basel, Switzerland)·2026
Same author

Photocontrol of Non-Adherent Cell Adhesion via Azobenzene-PEG-Lipid/Cyclodextrin Host-Guest Interactions.

International journal of molecular sciences·2026
Same author

MSC-derived osteogenic cell sheets on stiffness-tuned hyaluronic acid-gelatin hydrogels.

Journal of materials chemistry. B·2026

Related Experiment Video

Updated: May 14, 2026

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres
09:39

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres

Published on: June 1, 2012

Enzymatically Crosslinked Chitosan-Hyaluronic Acid Layer-by-Layer Microcapsules with Controlled Permeability and

Ririko Terada1, Shinji Sakai1

  • 1Department of Materials Engineering Science, Graduate School of Engineering Science, The University of Osaka, Toyonaka 560-8531, Osaka, Japan.

Polymers
|May 13, 2026
PubMed
Summary

Researchers developed covalently stabilized microcapsules for cell encapsulation. This novel method enhances structural integrity and reduces immune rejection, offering a promising platform for cell therapy applications.

Keywords:
cell therapycovalent crosslinkinghorseradish peroxidasemicrocapsule

More Related Videos

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
05:26

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Related Experiment Videos

Last Updated: May 14, 2026

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres
09:39

Constructing a Collagen Hydrogel for the Delivery of Stem Cell-loaded Chitosan Microspheres

Published on: June 1, 2012

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications
05:26

Fabrication of Size-Controlled and Emulsion-Free Chitosan-Genipin Microgels for Tissue Engineering Applications

Published on: April 13, 2022

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids
10:51

Microfluidic Fabrication of Core-Shell Microcapsules carrying Human Pluripotent Stem Cell Spheroids

Published on: October 13, 2021

Area of Science:

  • Biomaterials Engineering
  • Tissue Engineering
  • Immunology

Background:

  • Cell encapsulation protects transplanted cells from immune rejection.
  • Alginate microcapsules offer limited structural stability and permeability control.
  • Covalent stabilization is needed for robust cell encapsulation systems.

Purpose of the Study:

  • To develop covalently stabilized microcapsules for enhanced cell encapsulation.
  • To improve structural integrity and control membrane permeability.
  • To create a stable platform for cell therapy.

Main Methods:

  • Layer-by-layer assembly of phenol-modified chitosan and hyaluronic acid on alginate templates.
  • Covalent stabilization using horseradish peroxidase-mediated oxidative coupling.
  • Liquefaction of the alginate core to form hollow microcapsules.

Main Results:

  • Covalently stabilized microcapsules maintained structural integrity after core liquefaction.
  • Reduced permeation of γ-globulin, indicating improved immune barrier function.
  • Preserved β-cell viability and glucose responsiveness in vitro.

Conclusions:

  • Covalently stabilized microcapsules provide a robust and tunable platform for cell encapsulation.
  • This system demonstrates potential for improving cell survival and function in cell therapy.
  • The developed method offers a promising alternative to traditional alginate microcapsules.