Electrosprayed PLGA Nanoparticles for Dual Drug Delivery: Design, Optimization and Applications

Area of Science:

• Biomaterials Science
• Nanotechnology
• Drug Delivery

Background:

• Poly(lactic-co-glycolic acid) (PLGA) is a biocompatible, biodegradable polymer extensively used in drug delivery systems (DDSs).
• PLGA nanoparticles are versatile carriers due to their tunable properties and degradation into natural metabolites.
• Electrospray processing offers a scalable method for fabricating PLGA nanoparticles with controlled characteristics.

Purpose of the Study:

• To provide a comprehensive review of electrospray-fabricated PLGA nanoparticles.
• To explore the relationship between processing conditions, polymer structure, and nanoparticle performance.
• To analyze strategies for tailoring drug release profiles and designing advanced DDSs.

Main Methods:

• Review of electrospray (electrohydrodynamic atomization) technique for PLGA nanoparticle fabrication.
• Analysis of structure-property relationships in electrospray-PLGA nanoparticles.
• Examination of drug release mechanisms (diffusion, degradation) and structural design strategies (core-shell, surface-functionalized).

Main Results:

• Electrospray enables precise control over nanoparticle size, morphology, and internal structure.
• Processing parameters significantly influence nanoparticle formation and drug release kinetics.
• Various structural designs can be achieved to enable controlled and sequential drug delivery.

Conclusions:

• Electrospray is a highly effective technique for engineering PLGA nanoparticles for advanced DDSs.
• Understanding process-structure-property relationships is key to optimizing nanoparticle performance.
• Further research into modeling and addressing technical challenges will advance electrospray-based drug delivery.