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NBR1-Mediated Selective Autophagy in Plant Development and Stress Responses
Xinye Li1, Yali Duan1, Jiyang Zhou1
1Xinjiang Key Laboratory of Biological Resources and Genetics Engineering, College of Life Science and Technology, Xinjiang University, Urumqi 830046, China.
Plants (Basel, Switzerland)
|May 13, 2026
Summary
Plant selective autophagy receptor NBR1 targets damaged cellular components for degradation. This process is crucial for maintaining plant homeostasis, development, and resilience against various environmental stresses.
Area of Science:
- Plant biology
- Molecular biology
- Cellular biology
Background:
- Autophagy is a vital cellular degradation pathway for maintaining homeostasis in plants.
- Selective autophagy utilizes receptors to target specific cargo for degradation.
- NEIGHBOR OF BRCA1 GENE1 (NBR1) is a key receptor mediating selective autophagy.
Purpose of the Study:
- To review current knowledge on NBR1 structure, function, and evolutionary conservation.
- To explore NBR1's cargo recognition mechanisms and its role in plant stress adaptation.
- To highlight NBR1's interactions with phytohormone signaling and the ubiquitin-proteasome system.
Main Methods:
- Literature review of existing research on NBR1 and autophagy in plants.
- Analysis of NBR1 structure-function relationships.
- Synthesis of data on NBR1's role in various stress responses.
Main Results:
- NBR1 links ubiquitinated or damaged cargo to ATG8-decorated autophagosomes via its AIM and UBA domains.
- NBR1-mediated selective autophagy is essential for proteostasis, plant development, and adaptation to abiotic and biotic stresses.
- NBR1 interacts with phytohormone signaling pathways and the ubiquitin-proteasome system.
Conclusions:
- NBR1 is a critical component of plant selective autophagy, contributing significantly to stress resilience.
- Understanding NBR1's mechanisms provides insights into plant adaptation strategies.
- Further research into NBR1's interplay with other cellular pathways can enhance crop improvement for stress tolerance.
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