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Related Experiment Video

Updated: May 14, 2026

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
04:34

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg

Published on: May 31, 2019

Continuous Infusion Pressure Measurement in Predefined Interfascial and Intramuscular Tissue Conditions: An Ex Vivo

Mateusz Wilk1,2, Karol Jedrasiak3, Aleksandra Suwalska4

  • 1Collegium Medicum, WSB University, 41-300 Dabrowa Gornicza, Poland.

Journal of Clinical Medicine
|May 13, 2026
PubMed
Summary

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Infusion pressure in perineural catheters differs between intramuscular and interfascial tissue in controlled ex vivo settings. However, the absolute pressure difference is small and not clinically applicable.

Area of Science:

  • Anesthesiology
  • Biomedical Engineering
  • Medical Devices

Background:

  • Perineural catheter migration is a significant cause of continuous nerve block failure.
  • This study investigated infusion pressure differences in predefined catheter-tissue environments.
  • The study focused on ex vivo conditions, not clinical displacement.

Purpose of the Study:

  • To compare low-rate infusion pressure between interfascial and intramuscular perineural catheter placements.
  • To assess pressure variations under controlled ex vivo conditions.
  • To determine if observed pressure differences have clinical relevance.

Main Methods:

  • Sixty porcine thigh specimens were used for ex vivo analysis.
  • Ultrasound guidance facilitated placement of multi-orifice catheters in interfascial or intramuscular locations.
Keywords:
catheterinfusionnerve blockpressureregional anesthesia

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Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
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Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

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Last Updated: May 14, 2026

A Novel Non-invasive Method for the Detection of Elevated Intra-compartmental Pressures of the Leg
04:34

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Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion
10:27

Real-Time Assessment of Spinal Cord Microperfusion in a Porcine Model of Ischemia/Reperfusion

Published on: December 10, 2020

  • Saline was infused at 5 mL/h, with normalized pressure recordings analyzed using Welch's t-test.

    • Main Results:

    • Mean normalized infusion pressure was significantly higher in intramuscular (0.3346 PSI) versus interfascial (0.1917 PSI) placements.
    • A statistically significant difference was observed (p = 7.22 × 10^-15) with a large effect size.
    • Despite statistical significance, the absolute pressure difference was small.

    Conclusions:

    • Mean normalized infusion pressure varied between interfascial and intramuscular catheter positions ex vivo.
    • The absolute pressure differences were minimal, lacking clinical discriminative ability.
    • Findings are exploratory, do not support clinical applicability, and do not define a usable threshold.