Related Experiment Video

Updated: May 14, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

Lipoprotein(a), Coronary Complexity, and Stent-Related Outcomes: Meta-Analytic Insights for the Interventional

Alberto Cereda1, Marco Stracqualursi2, Matteo Rocchetti3

  • 1Interventional Cardiology Unit, Department of Cardiology, San Carlo Borromeo Hospital, ASST Santi Paolo e Carlo, 20153 Milan, Italy.

Journal of Clinical Medicine
|May 13, 2026
PubMed

Insights

Elevated Lipoprotein(a) [Lp(a)] is linked to complex coronary artery disease and worse outcomes after percutaneous coronary intervention (PCI). This inherited risk factor may help identify high-risk patients for personalized treatment.

Area of Science:

  • Cardiology
  • Genetics
  • Interventional Cardiology

Background:

  • Lipoprotein(a) [Lp(a)] is an inherited cardiovascular risk factor.
  • Its precise role in coronary anatomical complexity and post-percutaneous coronary intervention (PCI) outcomes requires further elucidation.

Purpose of the Study:

  • To systematically review and meta-analyze the association between Lipoprotein(a) [Lp(a)] levels and coronary disease characteristics.
  • To evaluate the impact of Lipoprotein(a) [Lp(a)] on clinical and stent-related outcomes following PCI.
  • To explore the relationship between Lipoprotein(a) [Lp(a)] and aortic valve disease.

Main Methods:

  • Systematic review and meta-analysis of 26 relevant studies.
  • Evaluation of associations between circulating Lipoprotein(a) [Lp(a)] levels and various cardiovascular parameters.
  • Analysis of clinical outcomes, stent-related adverse events, and aortic valve disease.

Main Results:

  • Elevated Lipoprotein(a) [Lp(a)] correlates with increased coronary anatomical complexity.
  • Higher Lipoprotein(a) [Lp(a)] is associated with a greater risk of major adverse cardiovascular events post-PCI (HR 1.4).
  • Strongest associations observed for stent restenosis (OR 3.23) and target vessel revascularization (OR 2.6), alongside vulnerable plaque and aortic valve calcification.

Conclusions:

  • Elevated Lipoprotein(a) [Lp(a)] is significantly associated with complex coronary artery disease and adverse outcomes after PCI.
  • Lipoprotein(a) [Lp(a)] may serve as a crucial biological marker for identifying high-risk individuals.
  • Findings support personalized risk stratification and procedural decision-making in patients undergoing PCI.

Keywords:
coronary artery disease complexitylipoprotein(a)percutaneous coronary interventionrestenosisstent-related outcomes

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Related Concept Videos

Coronary Artery Disease V: Interprofessional Care01:27

Coronary Artery Disease V: Interprofessional Care

Interprofessional care for coronary artery disease includes pharmacological therapy and revascularization procedures.Pharmacological therapy for Coronary Artery Disease (CAD) aims to manage symptoms, prevent complications, and improve patient outcomes through various classes of medications:Antiplatelet Agents:Aspirin and Clopidogrel: These medications inhibit platelet aggregation, preventing blood clots, which is crucial for avoiding heart attacks and strokes. Doctors often prescribe these...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...