De Ritis Ratio as an Independent Predictor of In-Hospital Mortality in Surgically Treated Acute Aortic Dissection

Area of Science:

• Cardiology
• Thoracic Surgery
• Biomarker Research

Background:

• Acute aortic dissection (AAD) has high mortality, increasing with treatment delays.
• Current risk stratification for AAD patients needs improvement.
• Early identification of high-risk AAD patients is crucial for timely intervention.

Purpose of the Study:

• To investigate the association between the De Ritis ratio (DRr) and in-hospital mortality in patients surgically treated for AAD.

Main Methods:

• Retrospective analysis of 182 patients who underwent AAD surgery (2020-2025).
• Evaluation of demographic, clinical, laboratory, and echocardiographic data.
• Logistic regression and ROC analysis to assess DRr's predictive value.

Main Results:

• In-hospital mortality was 32.4% (59 patients).
• The DRr was significantly higher in non-survivors compared to survivors.
• DRr, age, lactate, and ejection fraction were independent predictors of mortality in multivariable analysis (AUC=0.701, cut-off=1.308).

Conclusions:

• The DRr is an accessible biomarker associated with in-hospital mortality in surgically treated AAD.
• DRr offers incremental prognostic value when combined with existing clinical and laboratory parameters.
• This ratio can aid in refining risk stratification for AAD patients.