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Metabolism-Mediated Regulation of Brain-Heart Interactions

Zemin Liu1, Ruiyun Peng1, Li Zhao1

  • 1Beijing Institute of Radiation Medicine, Beijing 100850, China.

International Journal of Molecular Sciences
|May 13, 2026
PubMed

Insights

Metabolic homeostasis is vital for brain-heart synergy. Disruptions in metabolism can lead to cardiovascular and cerebrovascular diseases, highlighting the critical link between metabolic regulation and overall health.

Area of Science:

  • Neuroscience
  • Metabolic regulation
  • Cardiovascular and cerebrovascular health

Background:

  • Cardiovascular and cerebrovascular diseases pose significant global health challenges.
  • The brain and heart have high metabolic demands and intricate interactions.
  • Metabolic homeostasis is fundamental for normal physiological functions and brain-heart synergy.

Purpose of the Study:

  • To review research on brain-heart interactions mediated by metabolic regulation.
  • To explore the mechanisms of neurometabolic, endocrino-metabolic, and immune-metabolic regulation.
  • To examine the impact of cardiac function on brain metabolism and vice versa.

Main Methods:

  • Literature review of existing research on brain-heart metabolism.
  • Analysis of studies focusing on metabolic regulation pathways.
  • Synthesis of findings on bidirectional brain-heart metabolic interactions.

Main Results:

  • Metabolic homeostasis disruption is a key factor in comorbidities.
  • Neurometabolic, endocrino-metabolic, and immune-metabolic pathways significantly influence brain-heart interactions.
  • Cardiac function impacts brain metabolism, and brain activity influences cardiac metabolism.

Conclusions:

  • Metabolic regulation is a critical mechanism underlying brain-heart interactions.
  • Understanding these metabolic links is essential for addressing cardiovascular and cerebrovascular diseases.
  • Further research into bidirectional brain-heart metabolic regulation is warranted.

Keywords:
brainheartmetabolicmetabolic regulation

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