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Enzymatic assay for the antitumor agent-N-(phosphonacetyl)-L-aspartic acid (PALA)
Cancer Treatment Reports
|January 1, 1979
Abstract:
A method is described for the assay of N-(phosphonacetyl)-L-aspartic acid in plasma or urine, based on inhibition of partially purified aspartate carbamoyltransferase from rat liver. Concentrations of N-(phosphonacetyl)-L-aspartic acid as low as 0.1 microgram/ml can be detected. Plasma disappearance and urinary excretion curves from one patient are shown as examples of the application of the method.