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Updated: May 14, 2026

An In Vitro Approach to Photodynamic Therapy
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An In Vitro Approach to Photodynamic Therapy

Published on: August 17, 2018

Photodynamic Therapy in Dermatology.

Antonio Di Guardo1,2, Marco Virone1, Umberto Gallo1

  • 1UOC of Dermatology, Department of Medical and Cardiovascular Sciences, "Sapienza" University of Rome, 00161 Rome, Italy.

International Journal of Molecular Sciences
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

Photodynamic therapy (PDT) offers a minimally invasive dermatological treatment. It effectively targets neoplastic, inflammatory, infectious, and aesthetic conditions by generating cytotoxic reactive oxygen species.

Keywords:
actini keratosisbasal cell carcinomadaylight photodynamic therapyfield cancerizationinfectious dermatologyphotodynamic therapyphotorejuvenation

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Area of Science:

  • Dermatology
  • Photodynamic Therapy
  • Oncology

Background:

  • Photodynamic therapy (PDT) is a minimally invasive treatment.
  • Its success depends on photosensitizer, light, and oxygen interaction.
  • PDT generates reactive oxygen species for selective cytotoxicity.

Purpose of the Study:

  • To review the mechanisms and clinical evidence of PDT in dermatology.
  • To explore PDT's applications in neoplastic, inflammatory, infectious, and aesthetic conditions.
  • To summarize current understanding and future directions of PDT.

Main Methods:

  • Comprehensive literature search including randomized trials, systematic reviews, and meta-analyses.
  • Inclusion of mechanistic and translational studies.
  • Narrative review approach.

Main Results:

  • Strong evidence for field-directed PDT in actinic keratosis and Bowen's disease.
  • Selective role in basal cell carcinoma; limited monotherapy use in squamous cell carcinoma due to recurrence.
  • Expanding utility in acne and infectious dermatoses; beneficial cosmetic applications.

Conclusions:

  • PDT is an adaptable therapeutic framework for various dermatological conditions.
  • It shows promise in oncology, inflammatory diseases, infections, and aesthetic treatments.
  • PDT is best integrated into mechanism-oriented, multimodal treatment algorithms.