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Related Concept Videos

Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...

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Related Experiment Video

Updated: May 14, 2026

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

Circulating Omentin Levels in Heart Failure: A Case-Control Study.

Diego Currò1, Edoardo Vergani1, Maria Anna Nicolazzi2

  • 1Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00136 Rome, Italy.

International Journal of Molecular Sciences
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

Lower omentin levels are observed in heart failure patients with reduced (HFrEF) and preserved ejection fraction (HFpEF). This adipokine is inversely linked to BMI and reduced in heart failure patients with COPD, suggesting a potential biomarker role.

Keywords:
HFpEFHFrEFheart failureomentin

Related Experiment Videos

Last Updated: May 14, 2026

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure
04:20

Integration of Brain Tissue Saturation Monitoring in Cardiopulmonary Exercise Testing in Patients with Heart Failure

Published on: October 1, 2019

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Cardiovascular diseases are a leading cause of death globally.
  • Heart failure (HF) is a critical endpoint, with phenotypes like HFrEF and HFpEF presenting distinct challenges.
  • HFpEF pathophysiology involves inflammation and metabolic issues, with adipokines potentially playing a role.

Purpose of the Study:

  • To investigate and compare circulating omentin levels in patients with HFrEF and HFpEF.
  • To explore the relationship between omentin, body mass index (BMI), and chronic obstructive pulmonary disease (COPD) in heart failure patients.

Main Methods:

  • Cross-sectional study comparing omentin levels.
  • Analysis of omentin in relation to BMI and COPD status in heart failure cohorts.

Main Results:

  • Omentin levels were significantly lower in both HFpEF and HFrEF patients compared to controls.
  • Omentin showed an inverse correlation with BMI.
  • Omentin levels were significantly lower in heart failure patients with COPD.

Conclusions:

  • Omentin may serve as a potential biological marker in heart failure.
  • Further research in diverse populations is needed to confirm the clinical significance of omentin in heart failure.