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Published on: October 1, 2019

Circulating Omentin Levels in Heart Failure: A Case-Control Study

Diego Currò1, Edoardo Vergani1, Maria Anna Nicolazzi2

  • 1Dipartimento di Medicina e Chirurgia Traslazionale, Università Cattolica del Sacro Cuore, 00136 Rome, Italy.

International Journal of Molecular Sciences
|May 13, 2026
PubMed

Insights

Lower omentin levels are observed in heart failure patients with reduced (HFrEF) and preserved ejection fraction (HFpEF). This adipokine is inversely linked to BMI and reduced in heart failure patients with COPD, suggesting a potential biomarker role.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • Cardiovascular diseases are a leading cause of death globally.
  • Heart failure (HF) is a critical endpoint, with phenotypes like HFrEF and HFpEF presenting distinct challenges.
  • HFpEF pathophysiology involves inflammation and metabolic issues, with adipokines potentially playing a role.

Purpose of the Study:

  • To investigate and compare circulating omentin levels in patients with HFrEF and HFpEF.
  • To explore the relationship between omentin, body mass index (BMI), and chronic obstructive pulmonary disease (COPD) in heart failure patients.

Main Methods:

  • Cross-sectional study comparing omentin levels.
  • Analysis of omentin in relation to BMI and COPD status in heart failure cohorts.

Main Results:

  • Omentin levels were significantly lower in both HFpEF and HFrEF patients compared to controls.
  • Omentin showed an inverse correlation with BMI.
  • Omentin levels were significantly lower in heart failure patients with COPD.

Conclusions:

  • Omentin may serve as a potential biological marker in heart failure.
  • Further research in diverse populations is needed to confirm the clinical significance of omentin in heart failure.

Keywords:
HFpEFHFrEFheart failureomentin

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