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Adrenergic antagonists, or sympatholytics, inhibit adrenoceptor activation driven by catecholamines or agonists. Based on their adrenoceptor specificity, adrenergic blockers can be categorized into two primary groups: α-adrenergic blockers (α-blockers) and β-adrenergic blockers (β-blockers). α-blockers interact with α1 and α2 subtypes of α-adrenoceptors.
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How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
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A Bioactive Benzyl Terpene from Acridocarpus smeathmannii Inhibits Human Prostate Smooth Muscle Contractility.

Oluwafemi Ezekiel Kale1,2,3, Claudia Huber2, Denis Schuldeis2

  • 1Department of Pharmacology and Therapeutics, Olabisi Onabanjo University, Ago-Iwoye 120101, Ogun, Nigeria.

Molecules (Basel, Switzerland)
|May 13, 2026
PubMed
Summary

A novel compound from Acridocarpus smeathmannii roots, FAH-01, significantly inhibits human prostate smooth muscle contractions. This natural product shows potential for treating conditions with increased muscle tone.

Keywords:
2-(5-Isopropyl-4-methoxy-2-methylbenzyl)phenolAcridocarpus smeathmannii rootsCAS Registry Number: 64421-22-3anticontractility studychamanenchemical characterizationtoxicity effect

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Area of Science:

  • Natural Product Chemistry
  • Pharmacology
  • Urology

Background:

  • Prostate smooth muscle overactivity contributes to lower urinary tract symptoms.
  • Natural products offer potential therapeutic agents for smooth muscle disorders.

Purpose of the Study:

  • To isolate and characterize bioactive compounds from Acridocarpus smeathmannii roots.
  • To evaluate the effects of isolated compounds on human prostate smooth muscle contractility.

Main Methods:

  • Isolation and structural elucidation of FAH-01 using chromatography and spectroscopy (2D NMR).
  • Organ bath experiments to assess FAH-01's effects on noradrenaline-, phenylephrine-, and electrically stimulated prostate smooth muscle.
  • DPPH radical-scavenging assay for antioxidant activity and Artemia salina for toxicity assessment.

Main Results:

  • FAH-01, a benzyl-terpene, was isolated and characterized.
  • FAH-01 significantly inhibited noradrenaline- (up to 72%) and phenylephrine- (up to 63%) induced contractions.
  • FAH-01 suppressed neurogenic contractions and demonstrated antioxidant activity, with early toxicity observed.

Conclusions:

  • FAH-01 is a potent inhibitor of human prostate smooth muscle contractility.
  • The compound interferes with adrenergic and neurogenic signaling pathways.
  • FAH-01 presents therapeutic potential for conditions involving increased prostate smooth muscle tone, warranting further investigation.