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Related Experiment Video

Updated: May 14, 2026

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
07:28

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Published on: April 6, 2017

Ex Vivo Characterization and In Vivo Nasal Delivery of Ropinirole-Loaded PEO-b-PCL/Tween 80/β-Cyclodextrin Systems in

Elmina-Marina Saitani1, Paraskevi Papakyriakopoulou1, Evangelos Balafas2

  • 1Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece.

Molecules (Basel, Switzerland)
|May 13, 2026
PubMed
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Intranasal colloidal dispersions significantly improve ropinirole hydrochloride delivery to the brain. This novel drug delivery system enhances both systemic and brain exposure compared to oral solutions.

Area of Science:

  • Pharmacology
  • Drug Delivery
  • Nanotechnology

Background:

  • Intranasal administration offers direct central nervous system (CNS) targeting.
  • Previous work developed hybrid colloidal dispersions using PEO-b-PCL block copolymers, Tween 80, and β-cyclodextrin derivatives for intranasal delivery.
  • These dispersions were designed for ropinirole hydrochloride (RH) delivery.

Purpose of the Study:

  • To evaluate the ex vivo permeation of RH through rabbit nasal mucosa using developed colloidal dispersions.
  • To determine the pharmacokinetic parameters of intranasally administered RH colloidal dispersions compared to oral and intranasal RH solutions in mice.
  • To assess the potential of these dispersions for efficient CNS targeting.

Main Methods:

  • Development and characterization of hybrid colloidal dispersions (PEO-b-PCL/Tw80/βCD/RH).
Keywords:
CNS targetingcolloidal dispersionex vivo permeation studiesintranasal drug deliverypharmacokineticsropinirole hydrochloride

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Last Updated: May 14, 2026

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  • Ex vivo permeation studies using rabbit nasal mucosa.
  • Pharmacokinetic analysis in C57BL/6J mice comparing intranasal dispersion (F4) with oral and intranasal RH solutions.
  • Assessment of systemic and brain exposure (AUC, Cmax, relative bioavailability).

    • Main Results:

    • All tested formulations significantly enhanced RH permeation compared to a pure RH solution.
    • The F4 formulation [(PEO-b-PCL1/Tw80/HPβCD)/RH 10:5] demonstrated superior performance.
    • F4 significantly increased systemic and brain exposure of RH, with high relative bioavailability (1815% serum, 363% brain) compared to oral administration, despite a lower dose.

    Conclusions:

    • The developed intranasal colloidal dispersion (F4) is a promising system for enhanced CNS targeting of ropinirole hydrochloride.
    • This delivery route offers significantly improved systemic and brain bioavailability compared to oral administration.
    • The study underscores the potential of intranasal delivery systems for efficient brain drug delivery.