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Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation01:27

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Updated: May 14, 2026

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Catalyst-Free Three-Component Synthesis of 3-Aminoalkyl Chromones Using Rongalite as a C1 Synthon.

Juanjuan Gao1, Xinlei Fu1, Ruoying Hu1

  • 1Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China.

Molecules (Basel, Switzerland)
|May 13, 2026
PubMed
Summary
This summary is machine-generated.

A new one-pot method synthesizes 3-aminomethyl chromones efficiently using readily available materials. This domino reaction avoids transition metals and oxidants, offering a simple route to valuable chromone derivatives.

Keywords:
aromatic amineschromoneso-hydroxyaryl enaminonesrongalite

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Published on: September 12, 2018

Area of Science:

  • Organic Synthesis
  • Medicinal Chemistry
  • Heterocyclic Chemistry

Background:

  • Chromones are a vital class of heterocyclic compounds with diverse biological activities.
  • Efficient synthetic strategies for 3-aminomethyl chromones are crucial for drug discovery and development.
  • Existing methods often require harsh conditions, expensive reagents, or multiple steps.

Purpose of the Study:

  • To develop a facile, efficient, and cost-effective one-pot synthesis for 3-aminomethyl chromones.
  • To explore a novel three-component reaction utilizing inexpensive raw materials.
  • To establish a metal- and oxidant-free protocol for aminomethylation and annulation.

Main Methods:

  • A one-pot, three-component reaction involving o-hydroxyaryl enaminones, aromatic amines, and rongalite as a C1 source.
  • Domino aminomethylation and annulation strategy.
  • Characterization of the synthesized 3-aminomethyl chromone products using standard spectroscopic techniques.

Main Results:

  • Successfully synthesized a series of 3-aminomethyl chromones in moderate-to-good yields.
  • The developed protocol is efficient, operationally simple, and uses inexpensive and readily available starting materials.
  • The reaction proceeds without the need for transition metals or external oxidants.

Conclusions:

  • A novel and practical synthetic route to 3-aminomethyl chromones has been established.
  • This method offers a sustainable and economical alternative for accessing valuable chromone scaffolds.
  • The developed strategy holds promise for the facile preparation of diverse chromone derivatives for further applications.