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Updated: May 14, 2026

Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Catalyst-Free Three-Component Synthesis of 3-Aminoalkyl Chromones Using Rongalite as a C1 Synthon
Juanjuan Gao1, Xinlei Fu1, Ruoying Hu1
1Jiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou 341000, China.
Abstract:
Herein, a facile and efficient strategy for one-pot synthesis of 3-aminoalkyl chromones from o-hydroxyaryl enaminones and aromatic amines using inexpensive rongalite as a C1 source has been developed. This three-component protocol enables domino aminomethylation and annulation of o-hydroxyphenyl enaminones without the need for transition metals or oxidants, featuring simple operation, a broad substrate scope, and readily available raw materials, providing a series of 3-aminomethyl chromones in moderate-to-good yields.
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