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Nuclear-Targeted Drug Delivery Systems for Cancer Therapy: Advances, and Challenges

Yonghui Liu1, Yanan Wu1,2, Yifan Wu1

  • 1School of Chemistry, Tiangong University, Tianjin 300387, China.

Molecules (Basel, Switzerland)
|May 13, 2026
PubMed

Insights

Nuclear-targeted drugs offer promising tumor therapy, but biological barriers limit their effectiveness. This review explores advanced delivery strategies to enhance drug entry into the nucleus for improved cancer treatment.

Area of Science:

  • Oncology
  • Drug Delivery
  • Nanotechnology

Background:

  • Nuclear-targeted drugs are crucial for cancer therapy, interacting with DNA or enzymes.
  • Biological barriers in vivo significantly hinder drug delivery to the nucleus, reducing therapeutic efficacy.
  • The nucleus is a primary target for anticancer agents due to its role in DNA replication and transcription.

Purpose of the Study:

  • To systematically review advanced delivery strategies for nuclear-targeted drug systems.
  • To explore the therapeutic applications of these systems in oncology.
  • To analyze current challenges and future opportunities in developing intelligent nuclear delivery platforms.

Main Methods:

  • Literature review of advanced drug delivery systems for nuclear targeting.
  • Analysis of therapeutic applications in various cancer models.
  • Discussion of challenges and future prospects for nuclear drug delivery.

Main Results:

  • Various advanced delivery strategies are being developed to overcome biological barriers.
  • Nuclear-targeted drug systems show potential in diverse oncological applications.
  • Significant challenges remain in achieving efficient and specific nuclear drug delivery.

Conclusions:

  • Advanced delivery systems are essential for overcoming barriers to nuclear drug targeting in cancer therapy.
  • Further research is needed to develop next-generation intelligent nuclear delivery platforms for enhanced oncology outcomes.
  • Optimizing drug delivery to the nucleus holds significant promise for improving cancer treatment efficacy.
Keywords:
anticancercontrolled releasedrug delivery systemnuclear-targetedtumor therapy

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