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Updated: May 14, 2026

Nanoparticle Delivery of an Oligonucleotide Payload in a Glioblastoma Multiforme Animal Model

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Published on: September 27, 2024

Nuclear-Targeted Drug Delivery Systems for Cancer Therapy: Advances, and Challenges.

Yonghui Liu¹, Yanan Wu^1,2, Yifan Wu¹

¹School of Chemistry, Tiangong University, Tianjin 300387, China.

Molecules (Basel, Switzerland)

|May 13, 2026

Summary

This summary is machine-generated.

Nuclear-targeted drugs offer promising tumor therapy, but biological barriers limit their effectiveness. This review explores advanced delivery strategies to enhance drug entry into the nucleus for improved cancer treatment.

Keywords:

anticancer controlled release drug delivery system nuclear-targeted tumor therapy

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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines

Published on: March 4, 2017

Area of Science:

Oncology
Drug Delivery
Nanotechnology

Background:

Nuclear-targeted drugs are crucial for cancer therapy, interacting with DNA or enzymes.
Biological barriers in vivo significantly hinder drug delivery to the nucleus, reducing therapeutic efficacy.
The nucleus is a primary target for anticancer agents due to its role in DNA replication and transcription.

Purpose of the Study:

To systematically review advanced delivery strategies for nuclear-targeted drug systems.
To explore the therapeutic applications of these systems in oncology.
To analyze current challenges and future opportunities in developing intelligent nuclear delivery platforms.

Main Methods:

Literature review of advanced drug delivery systems for nuclear targeting.
Analysis of therapeutic applications in various cancer models.
Discussion of challenges and future prospects for nuclear drug delivery.

Main Results:

Various advanced delivery strategies are being developed to overcome biological barriers.
Nuclear-targeted drug systems show potential in diverse oncological applications.
Significant challenges remain in achieving efficient and specific nuclear drug delivery.

Conclusions:

Advanced delivery systems are essential for overcoming barriers to nuclear drug targeting in cancer therapy.
Further research is needed to develop next-generation intelligent nuclear delivery platforms for enhanced oncology outcomes.
Optimizing drug delivery to the nucleus holds significant promise for improving cancer treatment efficacy.