Related Experiment Video
Updated: May 14, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and Bioactivity Studies of Benzimidazole-Chalcone Hybrids
Herman D Makgoathana1, Siyanda T Mthembu2, Thandi V Mhlanga3
1Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of Pretoria, Lynnwood Road, Hatfield, Pretoria 0002, South Africa.
Abstract:
Chalcones featuring α,β-unsaturated carbonyl group are associated with an extensive range of pharmacological properties. The synthesized derivatives of benzimidazole-chalcone are prominent classes of bioactive compounds that have demonstrated significant applications. Recently, there has been an encouraged demand for synthesizing aromatic N-heterocyclic α,β-unsaturated hybrids that comprise benzimidazole-chalcones, which could be evaluated for activities against several diseases. The current review presents the synthetic approaches of the recently prepared benzimidazole-chalcone compounds and their biological applications. The biological activity studies include cytotoxicity against several cancer cells, antibacterial, antifungal, antileishmanial, antimalarial, antiviral and antidiabetic activities. The in silico studies of hybridized benzimidazole-chalcones are also discussed. Therefore, the review shows the significance of benzimidazole-chalcone derivatives and their potential as effective bioactive agents.
More Related Videos
06:31Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
Published on: November 27, 2015
09:20Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
Published on: October 4, 2019
Related Concept Videos
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene
Nucleophilic Aromatic Substitution: Elimination–Addition
Reactions at the Benzylic Position: Halogenation
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship
Diazonium Group Substitution with Halogens and Cyanide: Sandmeyer and Schiemann Reactions
Directing and Steric Effects in Disubstituted Benzene Derivatives